Background and objectives Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Blocking absorption reduces the amount of cholesterol in chylomicrons, which eventually return to the liver with their cholesterol loads and contribute to VLDL production. Composition different lipids in diet • Triglycerides (> 90%) • Cholesterol • Cholesteryl esters • Phospholipids, and • Unesterified fatty All of the above varieties of lipids are also synthesized in body 3. 2. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect. Reducing triglycerides in REDUCE-IT 10' education - Feb. 11, 2020 - Prof. Deepak Bhatt, MD - Online CME. Important for cholesterol excretion: 1. A number of different food components are known to reduce plasma and LDL-cholesterol levels by affecting intestinal cholesterol absorption. Cholesterol absorption is aided by an increase in dietary fat components and is hindered by high fiber content. Facilitate intestinal lipid absorption by . As metabolic products of cholesterol. absorption) • Dosing & effect • 10 mg PO daily • Expect 15-25% ↓LDL-C Drug information: “Ezetimibe.” Drug Monograph. Gold Standard. Solubilizer. of cholesterol in bile. … Published August 1, 2017. Cholesterol absorption is aided by an increase in dietary fat components and is hindered by high fiber content. Cofactor for pancreatic lipase and PLA2. Cholesterol is both good and bad. Emulsifying factors for dietary lipids, a prerequisite step for efficient lipid digestion. Overview of lipid digestion 4. This preview shows page 32 - 40 out of 40 pages.. Cholesterol Absorption Inhibitors #3 Cholesterol Absorption Inhibitors #3 Pharmacokinetics o Absorbed in the GI tract o Metabolized in the liver, excreted in urine and feces Contraindications o Allergy o Pregnancy or lactation if combined with a statin This is the reason that a high intake of fiber is recommended to decrease blood cholesterol. Absorption of dietary cholesterol from the intestine is an important part of cholesterol homeostasis and represents the first step that allows dietary cholesterol to exert its metabolic effects. They include: soluble fibers, phytosterols, saponins, phospholipids, soy protein and stearic acid. This is the reason that a high intake of fiber is recommended to decrease blood cholesterol. Overview of lipid digestion 5. Graphic original. PPT Cholesterol absorption (PPTX 1.6MB) Share this page with your colleagues and friends: Continue reading: 4 Things a cardiologist should know about triglycerides. 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